| Floors of
| Base Health||280|
|Unlocked By|| Defeating|
|Items Dropped|| Cube of Meat|
Ball of Bandages
|“||Then I saw when the Lamb broke one of the seven seals, and I heard one of the four living creatures saying as with a voice of thunder, “Come.” I looked, and behold, a white horse, and he who sat on it had a bow; and a crown was given to him, and he went out conquering and to conquer.||”|
— Revelation 6:1-2˄ New American Standard Bible (NASB)
Pestilence is an enemy in The Binding of Isaac: Rebirth. It appears as a Boss on The Caves and The Catacombs Floors and as a Monster on later Floors.
Pestilence has two phases which are as follows:
- Pestilence will float around the room, occasionally coughing out maggots and firing IPECAC (explosive) tears. As it floats, it will leave a trail of green creep.
- Pestilence will lose its head at half health. The horse will cough out Flies and the body will shoot out IPECAC (explosive) tears.
Pestilence has one Champion variant.
- Pestilence will be white and leave a white, non-lethal creep trail instead of a green one. It will also shoot 6 bullets in an asterisk pattern instead of IPECAC shots and will spawn spiders instead of Flies.