- Skulls are found in The Dank Depths. They will either contain nothing, a Host, a Card, a Black Heart, a Dry Baby, or a Ghost Baby.
- The Dank Depths II will always house the Mom Boss fight in the Boss Room.
- If the player defeats Mom in under 20 minutes, a door to Boss Rush will open.
- Some Rocks or Props in The Dank Depths will spawn as Spikes.
- Some of the Dank Depths' enemies will spawn in "dank", such as the Dank Death's Head, the Dank Bony, and the Dank Globin.
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