- Skulls are found in The Depths. They will either contain nothing, a Host, a Card/Rune, a Black Heart, a Ghost Baby, or a Dry Baby.
- The Depths II will always have Mom as the Boss in the Boss Room. The Boss Room cannot be exited through a door once entered.
- If the player defeats Mom in under 20 minutes, they are allowed to exit this Room into Boss Rush.
- The theme for The Depths is Abyss, going along with the idea that The Depths is deep underground.
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