- Growths are found in The Womb. They will either contain nothing, shoot tears in an asterisk pattern, or contain a Red Heart/Soul Heart.
- The Womb II will always have Mom's Heart (It Lives if unlocked) as the Boss in the Boss Room. The Boss Room cannot be exited through a door once entered.
- If Isaac has beaten Mom's Heart (or It Lives) and if the time is under 30:00, the door to the Blue Womb will open.
- The theme for The Womb is Viscera.
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